IgE to Allergen Components (Component resolved Diagnostics, CRD) including ISAC

Peanut, Hazelnut, Eggs, Insect Venom, Latex, Wheat


We offer a service for IgE to various purified allergen components, either as individual components associated with a specific allergen or as a 112 allergen array (ISAC).  The indications for CRD testing are when there is no good history to determine the significance of a weak positive IgE result or skin prick test to a conventional allergen extract.  The presence of IgE to certain components is associated with a higher risk of systemic reactions than to others.

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Component Resolved Diagnostics


Immunology Laboratory

Specimen Type:

Serum or Plasma


If samples have to be stored prior to dispatch, please keep at 4°C

Posting Details:

Room temperature

Posting Address:

Department of Immunology, City Hospital, Dudley Road, Birmingham, B18 7QH

Clinical Use:

Determine the clinical significance of certain positive IgE or skin prick tests


Discriminates IgE directed against clinically significant /"high risk" proteins from false positive "low risk" proteins


3 working days for individual components
3 weeks for ISAC®

External QA Scheme:

UK NEQAS for specific IgE

CPA Accredited Lab/Test:

Full accreditation

Key Contact:

Shabir Rajpar

Email: info@cityassays.org.uk

Tel: 0121 507 4258

Clinical Lead for this Assay:

Dr Sadia Noorani

Tel: 0121 507 5157






  SWBH NHS Trust 2018