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SWBH Pathology News 0409

6-TGN Assay Version 1.01 now available

With increasing interest in checking the active metabolites of azathiopurine we have now updated the user information leaflet for our 6-TGN assay. The link to the PDF was not working for a while but should be now.... thanks for your patience.

Updated User Information Leaflets

Please note that we have updated user information for the following tests on Friday 15th may 2009:

UGT1A1*28 Assay Now Available

 

UGT1a1 LightCycler Melt Curves

Melting curves for our real time PCR of UGT1A1*28

We have now completed our development of a new assay for  the UGT1A1*28 polymorphism located in the promoter region of the uridine diphosphate glucuronsyltransferase gene. Key uses include:

  • For the diagnosis of Gilbert's Syndrome. Patients with this benign condition sometimes undergo unnecessary examinations including tests such as 48 hour diet and liver scans. The determination of the underlying genetic status can give a clearer diagnostic approach.
  • To assess patients prior to commencing on drug therapies where UGT1A1 is involved in metabolism. The most well known such pharmacogenomic situation is treatment with Irinotecan where some advocate that patients should be pre-screened prior to commencing treatment with patients of the 7/7 genotype having their initial dose modified.

Further details .....

Electronic Result Return

We can now give you access to electronic look-up of results. This is via a secure https website. You are issued with a password and username and can gain access to look at results on patient samples sent from your laboratory. This is of particular interest where printed copy reports have gone astray and can save your staff time in phoning us. Also where you want to reduce turn round time even more - for example with our pharmacogenomic tests such as TPMT and UGT1A1*28 where you can improve on our already very tough turn round targets of 2 and 3 working days respectively by cutting out the postal return time.

To enquire about having your laboratory set please email:

alan@cityassays.org.uk

About Us

The Pathology Department at Sandwell and West Birmingham Hospitals NHS Trust serves a large population in Birmingham and the Black Country. Our main laboratatory is situated close to Birmingham City Centre. We are a busy clinical department committed to offering our patients up to date pathology support of the highest standard. A number of our laboratories have specialist interests with assays being offered to the rest of the NHS.

These web pages offer information on the specialist assays that we offer, including information on turnaround times as well as the ability to download user information leaflets.

We put great importance on ensuring that we communicate with those that refer tests to us and this website is just one example of this.

Please don't hesitate to contact us if you would like to know more.

 

 

 

 

 

CPA accredited laboratory